WEEK 06

PROTEIN FOLDING




1. How many molecules of amino acids do you take with a piece of 500 grams of meat? (on average an amino acid is ~100 Daltons)



500g=3e26 dalton, /100 dalton = 3e24



CHOSEN PROTEIN: NORRIN









Norrin is a cysteine-rich growth factor that is required for angiogenesis in the eye, ear, brain, and female reproductive organs.

MRKHVLAASFSMLSLLVIMGDTDSKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMV

LLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATY

RYILSCHCEECNS

Length:133

PDB id :4MY2













structure solved:Deposited: 2013-09-27
protein family



[Superfamily, evalue = 8.69e-03]cl21545, Glycoprotein hormone beta chain homologues ;This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.